In this study a one step method for the preparation of substituted anilides of\r\nquinoline-2-carboxylic acid was developed. This efficient innovative approach is based on\r\nthe direct reaction of an acid or ester with substituted anilines using microwave irradiation.\r\nThe optimized method was used for the synthesis of a series of eighteen substituted\r\nquinoline-2-carboxanilides. The molecular structure of N-(4-bromophenyl)quinoline-2-\r\ncarboxamide as a model compound was determined by single-crystal X-ray diffraction.\r\nIt crystallizes in the monoclinic space group with four molecules within the unit cell and\r\nthe total structure of the compound can be described as ââ?¬Å?a slightly screwed boatââ?¬Â.
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